Polynucleotides are emerging as one of the most talked-about treatments of the moment. But what are they? Do they really work? And how can you ensure the best results post-treatment? Let’s explore the science behind polynucleotides, their effectiveness, and how proper aftercare including products like AfterMED - plays a vital role in maximising their benefits.

🔬 What Are Polynucleotides?

Polynucleotides are biopolymers made of nucleotide chains, derived from DNA and RNA fragments. These molecules are naturally occurring and are often extracted from fish (typically salmon) for cosmetic and medical use. Their primary role in the body is cell regeneration, DNA repair, and tissue healing—functions that make them ideal candidates for aesthetic treatments.

When injected into the skin, polynucleotides act as biostimulators, triggering processes such as:

• Fibroblast activation – boosts collagen and elastin production.

• Tissue hydration – enhances skin elasticity and reduces fine lines.

• Angiogenesis – promotes new blood vessel formation, improving oxygen and nutrient delivery.

• Anti-inflammatory response – accelerates wound healing and reduces redness or swelling.

This makes them suitable for a range of indications including under-eye hollows, skin laxity, acne scarring, and even lip rejuvenation.

📈 Are Polynucleotides Effective?

The short answer: yes—especially when administered correctly and with proper aftercare.

Clinical Backing

Numerous studies support the efficacy of polynucleotide treatments:

• A 2022 review in the Journal of Cosmetic Dermatology found that polynucleotide injections significantly improved skin texture, elasticity, and hydration after 3–4 sessions.

• A UK-based trial showed 90 % of patients experienced reduced superficial fine lines and wrinkles in the periorbital area after treatment- Dr Sarwar.

🧴 Aftercare Matters: Why AfterMED Is Essential

While polynucleotide injections are safe and effective, aftercare is crucial to ensuring optimal outcomes. That’s where AfterMED products come in.

AfterMED for Post-Polynucleotide Recovery

AfterMED is a specially formulated aftercare range designed for injection-based skin treatments, including polynucleotides. Its benefits include:

• Soothing inflammation post-injection

• Protecting compromised skin barriers

• Hydrating deeply to support tissue regeneration

• Reducing the risk of infection with antimicrobial properties

Incorporating AfterMED immediately after treatment can help calm the skin and enhance the absorption of active ingredients, ensuring your body makes the most of those hard-working polynucleotides.

🧠 Final Thoughts: Do Polynucleotides Work?

Yes and the science is on their side. Polynucleotides are more than just a trend; they’re a regenerative breakthrough that’s redefining how we approach anti-aging and skin restoration. 

But to truly get the most from your treatment, don’t underestimate the power of aftercare. Incorporating a targeted solution like AfterMED can dramatically improve your recovery and amplify your results.

References:

• Gentile, P., & Garcovich, S. (2022). Use of Polynucleotides for Skin Rejuvenation: A Review of Clinical Applications and Mechanisms of Action. Journal of Cosmetic Dermatology, 21(1), 10–18.
  

• Cavallini, M. et al. (2020). Polynucleotide-Based Dermal Fillers: Efficacy, Indications, and Clinical Evidence. Aesthetic Surgery Journal Open Forum, 2(3), ojaa027.
  

• Lee, H., Kim, H., & Cho, Y. (2021). The Effects of Polynucleotide and Hyaluronic Acid Combinations on Fibroblast Proliferation and Collagen Production. Dermatologic Therapy, 34(5), e14948.
  

• Aesthetics Journal (UK) – Market Insight Report 2024: Injectables and Emerging Trends.
  URL: www.aestheticsjournal.com

• GlobalData – Aesthetic Injectable Trends Report 2024: Polynucleotides Market Growth.
  Available through subscription: www.globaldata.com

• AfterMED Product Information – Manufacturer’s Data Sheet & Clinical Usage Guidelines (2024).
  Available from: www.aftermedskin.com (verify through product packaging and distributor literature)

• EADV Congress Abstracts (2023) – Biostimulatory Aesthetics: Emerging Evidence for Polynucleotides in Skin Restoration.
  European Academy of Dermatology and Venereology.
  URL: www.eadv.org